The desire to eliminate pain has been since ancient times, and freedom from pain is a kind of happiness! The pain of the body is the enemy of health. Looking through the history of human anti-pain, a major breakthrough in anti-pain drugs began in the late 19th century, when scientists purified aspirin and morphine, which are effective analgesics in the literature. However, aspirin is not effective in analgesic, but also has stomach damage, inhibits platelet aggregation, and the risk of stomach bleeding. However, morphine has a good analgesic effect, but both side effects need to be carefully used under strict supervision. New drugs developed in the twentieth century are still basically taking the route of aspirin, non-steroidal anti-inflammatory drugs (to reduce inflammation and relieve pain) and morphine (for morphine receptors in the central nervous system).
However, in order to achieve a good analgesic effect, and to reduce and alleviate adverse drug reactions, new anti-pain drugs have been developed and effectively curbed some clinical pain patients. The following is a list of new drugs currently used in clinical practice:
Tramadol 37.5mg+APAP 325mg
Ultracet is a compound that has two components. Tramadol is a central analgesic that is a potent opioid analgesic that relieves moderate to moderate pain. APAP is a commonly used painkiller. , acting on the center. The two drugs are used together, and the ratio of the golden ratio of the two dose ratios is obtained by experiments. The so-called analgesic effect is different, and the addition of individual drugs also causes the side effects to be lighter. The clinical upper limit is for patients with moderate to severe pain and must meet the following criteria: Patients who are unable to control pain or have serious side effects after treatment with other analgesics, or non-steroidal anti-inflammatory drugs (NSAIDs). Non-cancer patients should be accompanied by a pain assessment report for more than five days and reassessed every three months. The content must include VAS and VRS (Visual Analogue Scale and Verbal Rating Scale) for pain intensity and pain relief.
Butorphanol tartrate 10mg/ml
All right nasal spray 2.5ml / bottle; 0.1ml / spray
Butaro NS is mainly used for pain relief after acute pain. The main ingredient is butorphanol, which belongs to the analgesic agent acting on opioid receptors. A bottle under normal use, about 15 sprays of more drugs, each spray Butaro NS is about 0.1mI aqueous solution, containing butorphanol 1 mg, about the dose required for pain relief three days after surgery. Analgesic effect occurs within 15 minutes, the maximum analgesic effect occurs 30-60 minutes after use, and the analgesic time can be maintained for 4-5 hours. The specificity of this medicine is: strong; rapid pain relief; nasal spray use, easy to operate, for acute pain after surgery, can provide an alternative to oral painkillers, invasive injections.
Nalbuphine, an analgesic agent acting on opioid receptors, has a different pharmacological mechanism than traditional opioid analgesics (such as morphine), acting on κ opioid receptors, and antagonizing mu opioid receptors. It is clinically used to relieve moderate to severe pain and can also be used as an adjuvant for balanced anesthesia. Such as anesthesia before and after surgery, and obstetric anesthesia during labor pain. Side effects are associated with pharmacological mechanisms, lack of morphine respiratory depression and low addiction. Only injections can be injected into the veins, muscles and under the skin, and cannot be taken orally.
Buprenorphine sublingual ingot 0.2mg / ingot
Temgesic was successfully developed by the British pharmaceutical company in 1960. It was launched in 1978. After being approved by the US FDA in 1985, it was widely used in the treatment of acute and chronic pain. In recent years, it has also been used to treat addiction. Adult doses are 1-2 spindles each time. Clinically used for moderate to severe pain, such as postoperative pain, severe trauma, cancer pain, severe back pain, kidney stone or gallstone colic, sudden arthritis, herpes zoster, sciatica, etc. Auxiliary agent.